Tatamagouche was first settled upon by the French Acadians in the early 1700s. Tatamagouche acted as a transhipment point for materials headed to Louisbourg. Unfortunately, today all that remains of the original town of Tatamagouche are its dykes, and some French place names. In 1755, the British came and expelled the Acadians, destroying the village. Ten years later, the ravaged land was given to British Colonel Joseph Frederick Wallet DesBarres. Near the end of the 18th century, Scottish immigrants began flocking to the area as the land was again liveable.

Today, Tatamagouche is a wonderful place to come and relax. Come and see the historical museum, the Fraser Cultural Centre, the Sutherland Steam Mill Museum or the Dorje Denma Ling, which is a Buddhist retreat center. Drysdale Falls is a scenic water fall 10 m (32.8 ft.) tall. Tatamagouche was World renowned for its creamery, via the Tatamagouche Creamery, which began in 1925 and has since closed, but not its archives, where visitors can still see what went on here during the cream producing days. Tatamagouche is located 148 km (92 mi.) from Halifax.

Tatamagouche accommodations offer bed and breakfasts, inns, motels, cottages and campgrounds.